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肖建教授

肖建,男,教授,硕士研究生导师。山东省杰出青年基金获得者, 山东省青年科技奖获得者,山东省自然科学学术创新奖获得者, 手机网投娱乐大全有机化学学科带头人, 功能有机分子团队负责人, 手机网投娱乐大全高层次引进人才,山东省优秀硕士论文指导教师, 手机网投娱乐大全优秀学士论文指导教师, 手机网投娱乐大全研究生创新计划指导教师。19816月生,山东昌乐人,中共党员。2005年硕士毕业于南开大学元素有机化学研究所,2009年博士毕业于新加坡南洋理工大学化学与生物化学系,师从有机化学家Teck-Peng Loh教授。2009-2010年在南洋理工大学从事博士后研究。2010-2012年在中国科平台大连化学物理研究所任副研究员。2013-2014年在美国加利福尼亚州The Scripps Research Institute做博士后研究, 师从生物化学家Carlos F. Barbas III教授。20129月起为手机网投娱乐大全网投娱乐大全教授,有机化学学科带头人,功能有机分子实验室及团队负责人。迄今为止,已经以第一或通讯作者在Angew. Chem. Int. Ed.等国际顶尖或权威期刊上发表SCI论文46, 影响因子6.0以上14篇,总引用次数超过1000次,其中单篇引用超过200次。主持国家自然科学基金、山东省杰出青年基金、山东省重点研发计划等项目7项,授权国际PCT专利2, 受邀撰写英文综述3篇,主编英文学术著作一部。
课题组网站见:
/content/kytd/11d1acdf75394eaeadbfeb7a72c497cc

教育背景

1998-2002 曲阜师范大学化学与化工平台 学士

2002-2005 南开大学元素有机化学研究所 硕士

2005-2009 新加坡南洋理工大学化学与生物化学系博士 (Prof Teck-Peng Loh)

工作经历

2009-2010 新加坡南洋理工大学化学与生物化学系博士后 (Prof Teck-Peng Loh)

2010-2012 中国科平台大连化学与物理研究所副研究员

2013-2014 美国The Scripps Research Institute博士后 (Carlos F. Barbas III)

科研项目

国家自然科学基金 21102142, 21702117, 21776148

农业部948计划 2016-X28

山东省自然科学杰出青年基金 JQ201604

山东省重点研发计划公益类专项 2017GSF218073

山东省自然科学基金面上项目 ZR2016BM07

山东省自然科学基金博士基金 ZR2017BB005

山东省中青年科学家奖励基金 BS2013YY002

青岛市应用基础研究计划青年科技专项14-2-4-70-jch

青岛市应用基础研究计划科技惠民专项 16-6-2-29-nsh

药物合成与优化湖北省重点实验室开放基金 OPP2015YB01, OPP2015ZD02

手机网投娱乐大全高层次人才启动基金 6631112323,6631115015

手机网投娱乐大全研究生创新计划 QYC201616

国家大学生创新创业训练计划 201410435050

荣誉奖励

2017 第十一届山东省青年科技奖

2017 山东省高等学校优秀科研成果奖一等奖

2016 山东省自然科学杰出青年基金

2016 山东省自然科学学术创新奖

2016 手机网投娱乐大全研究生创新计划

2014 手机网投娱乐大全优秀学士论文指导教师

2015 手机网投娱乐大全优秀学士论文指导教师

2015 The Advisory Board, Merck Index Online

2015 Asian Core Program Lectureship Award

2015 山东省高等学校优秀科研成果奖三等奖

2013 山东省高等学校优秀科研成果奖三等奖

2013 手机网投娱乐大全优秀学士论文指导教师

2012 中国科平台大连化物所科技创新奖

2010 第八届亚欧化学会议最佳墙报奖 (AES-MMEOS 2010)

2004 南开大学陈茹玉奖学金

研究兴趣与研究方向

面向国家重大战略需求和国际前沿重要科学问题,通过化学键的断裂与重组及多学科交叉与融合,解决新一代物质创造与转化过程中的重要科学问题,高效创造功能新分子,形成了鲜明的研究特色和研究方向:(1)新一代物质转化合成方法学;(2)功能分子的设计合成及应用;(3)药物合成新工艺及新药创制;(4)生物质能源转化及能源化学。

Publications

49. Zhu Shuai, Chen Chunqi, Xiao Mingyan, Yu Liping, Wang Liang*, Xiao Jian*, Construction of the Tetrahydroquinoline Spiro Skeleton via Cascade [1,5]-Hydride transfer-involved C(sp3)-H Functionalization “on Water” Green Chem. 2017, in press. (IF = 9.125)

48. Xiao Mingyan, Dong Haoxun, Xu Lubin, Yu Liping and Xiao Jian*, “SN1-type Alkylation of N-Heteroaromatics with Alcohols” Org. Lett. 2017, in press. (IF = 6.579)

47. Li Shuai-Shuai, Fu Shiheng, Wang Liang, Xu Lubin and Xiao Jian*, “t-BuOK-Mediated Oxidative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes” J. Org. Chem. 2017, 82, 8703. (IF = 4.849)

46. Xiao Jian*, Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun*, Wang Chang-Yun, “Catalyst-Free Dehydrative SN1-Type Reaction of Indolyl Alcohols with Diverse Nucleophiles on Water” Green Chem. 2016, 18, 1032. (IF = 8.51,Hot Paper, Highlighted by X-mol资讯网站,科技日报,中国网)

45. Wang Liang, Xiao Jian*, “Hydrogen-Atom Transfer Reactions” Topics in Current Chemistry, 2016, 374, 17. (IF=4.46, Invited Review)

44. Wang Liang, Xiao Jian*, “C(sp3)-H Bond Functionalization by Sequential Hydride Transfer/Cyclization: Electronic Effect and Steric Effect Controlled Regioselectivity” Org. Chem. Front. 2016, 3, 635. (IF=4.69, Inside Front Cover, Hot Articles in March 2016)

43. Zhao Huaili, Xiao Mingyan, Wang Liang * and Xiao Jian *, “Bifunctional Thiourea Catalyzed Asymmetric Michael Addition of Anthrone to Methyleneindolinones” RSC Adv. 2016, 6, 38588 (IF=3.84)

42. Liu Jian, Wang Xiaoxiao, Wang Liang, Xu Lubin, Hao Zhihui and Xiao Jian*, “Fluorinated Alcohol-Mediated [4+3] Cycloaddition Reaction of Indolyl Alcohols with CyclopentadieneOrg. Biomol. Chem. 2016,14,11510. (IF = 3.56)

41. Dong Haoxun, Xu Lubin, Li Shuai-Shuai, Wang Liang, Shao Chang-Lun, Xiao Jian*, “Facile Synthesis of Azaarene-substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp3)-H Functionalization” ACS Comb. Sci. 2016, 18, 604. (IF=3.32)

40. Liu Jian, Wang Xiaoxiao, Xu Lubin, Hao Zhihui, Wang Liang* and Xiao Jian *, “One Step Synthesis of 2-Alkenylchromanes via Inverse Electron-Demand Hetero-Diels-Alder Reaction of o-Quinone Methide with Unactivated Dienes” Tetrahedron 2016, 72,7642. (IF = 2.65)

39. Zhao Huaili, Wang Xiaoxiao, Wang Liang and Xiao Jian *, “Regioselective Michael Addition of Anthrone to Methyleneindolinones” Synthesis, 2016, 48, 2112. (IF=2.65)

38. Fu Shiheng, Wang Liang, Dong Haoxun, Yu Junqiang, Xu Lubin and Xiao Jian*, “Facile Synthesis of 2-Alkenylazaarenes via Dehydrative Coupling of 2-Methylazaarenes with Aldehydes on Water” Tetrahedron Lett. 2016, 57, 4533. (IF = 2.35)

37. Zhang Xianhui, Li Shuai-Shuai, Wang Liang, Xu Lubin,Xiao Jian*, Zhen-Jiang Liu*, 2-Methylquinoline Promoted Oxidative Ring-Opening of N-Sulfonyl Aziridines with DMSO: Facile Synthesis of α-Amino Aryl Ketones, Tetrahedron 2016, 72, 8073. (IF = 2.35)

36. Zhu Shuai, Xu Lubin, Wang Liang*, Xiao Jian*, “Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols” Chin. J. Org. Chem. 2016, 36, 1229. (IF=1.87)

35. Liu Qing, Dong Xu, Li Jun, Xiao Jian, Dong Yunhui,* and Liu Hui*, “Recent Advances on Palladium Radical Involved Reactions” ACS Catal. 2015, 5, 6111 (IF=9.31)

34. Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun,* Wang Chang-Yun, Xiao Jian*, “Fluorinated Alcohol-Mediated SN1-Type Reaction of Indolyl Alcoholswith Diverse Nucleophiles” Adv. Syn. Catal. 2015, 357, 4023 (IF = 6.45,VIP and Cover Picture, Highlighted by X-mol资讯网站,科技日报,中国网)

33. Wang Xiaoxiao, Liu Jian, Xu Lubin, Hao Zhihui, Wang Liang*,Xiao Jian*, “Friedel–CraftsAlkylation of Heteroarenes and Arenes with Indolyl Alcohols for Construction of 3,3-Disubstituted Oxindoles” RSC Adv., 2015, 5, 101713. (IF=3.84)

32. Xu Lubin, Shao Zhuzhou, Wang LiangXiao Jian*, “Tandem sp3 C-H Activation/Decarboxylation of 2-Alkyl Azaarenes with Coumarin-3-Carboxylic Acid”  Org. Lett., 2014, 16, 796. (IF = 6.73)

31. Wang Liang, Xiao Jian*, “New Advancement of Cascade [1,5]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)-H Bonds”  Adv. Syn. Catal., 2014, 356, 1137. (IF = 6.45)

30. Xiao Jian,*Chen Yuye, Zhu ShuaiWang Liang, Xu Lubin, Wei Hongtao, “Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen-6-one Derivatives by Domino Reaction of 4-alkynyl-2-oxo-2H-chromene-3-carbaldehydes” Adv. Syn. Catal., 2014, 356, 1835. (IF = 6.45)

29.WangLiang,XiaoJian*,LohTeck-Peng*,“Organocatalyticβ-Functionalization of Saturated Carbonyl Compounds---The State of the Art” ChemCatChem, 2014, 6, 1183.(IF = 4.72)

28. Shao Zhuzhou, Xu Lubin, Wang Liang, Wei Hongtao, Xiao Jian,* “Catalyst-free Tandem Michael Addition/Decarboxylation of (thio)coumarin-3-carboxylic Acids with Indoles: Facile Synthesis of Indole-3-substituted 3,4-dihydro(thio)coumarins” Org. Biomol.Chem., 2014, 12, 2185. (IF = 3.56)

27. Wang Liang,Chen Yuye, Xiao Jian*, “AlkylideneindoleniniumIons and Alkylideneindolenine: Key Intermediates for Asymmetric Synthesis of 3-Substituted Indoles”

Asian J. Org.Chem. 2014, 3, 1036. (IF = 3.28)

26. Shao Zhuzhou, Wang Liang, Xu Lubin, Zhao Huaili and Xiao Jian *,“Facile Synthesis of Azaarene-2-substituted Chromanone Derivatives via Tandem sp3 CH Functionlization/Decarboxylation of Azaarenes with 4-oxo-4H-chromene-3-carboxylic acid”  RSC Advances, 2014, 4, 53188. (IF = 3.84)

25. Xu Lubin, Shao Zhuzhou, Wang Liang, Zhao Huaili and Xiao Jian *,” Catalyst-Free Synthesis of (Z)-2-Alkenylquinoline Derivatives via C(sp3)-H Functionalization of 2-Methylquinolines” Tetrahedron Lett. 2014, 55, 6856. (IF = 2.35)

24. Yu Xinzhang, Yu Songjie, Xiao Jian, Wan Boshun, Li Xingwei*, “Rhodium(III)-Catalyzed Azacycle-Directed Intermolecular Insertion of Arene CH Bonds into α-Diazocarbonyl Compounds” J. Org. Chem. 2013, 78, 5444. (IF = 4.79)

23. Xiao Jian*, “Merging Organocatalysis with Transition Metal Catalysis: HighlyStereoselective Alkylation of Aldehydes” Org. Lett. 2012, 14, 1716. (IF = 6.73) (Highlighted by Synfacts 2012, 8, 0749)

22. Xiao Jian*,“Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes” ChemCatChem 2012, 4, 612. (IF = 4.72)

21. Liang Tao, Xiao Jian*, Xiong ZhiyiLi Xingwei*, “Organocatalytic Asymmetric 1,4 Addition of Aldehydes to Acridiniums Catalyzed by a DiarylprolinolSilyl Ether” J. Org. Chem. 2012, 77, 3583. (IF =4.79)

20. NiuRui, Xiao Jian*, Liang Tao, Li Xingwei*, “Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-Oxindoles via Bronsted Acid-Catalyzed sp3C-H Functionalization” Org. Lett., 2012, 14, 676. (IF = 6.73)

19. Xiao Jian, Zhao Kai, LohTeck-Peng*,“The OrganocatalyticEnantioselective Acid Free Alkylation of Aldehydes in Fluorinated Alcohols” Chem. Comm. 2012, 48, 3548. (IF = 6.57)

18. Huang Fen, Xu Lubin, Xiao Jian*, “OrganocatalyticEnantioselectiveDehydrogenative α-Alkylation of Aldehydes with Benzylic Compounds” Chin. J. Chem. 2012, 30, 2721. (IF = 1.87) (Invited Special Issue of "Asymmetric Synthesis", one of the most accessed papers from 11/2012 to 10/2013).

17. NiuRui, Yang Shiying, Xiao Jian*, Liang Tao, Li Xingwei*, “Yb(OTf)3-Catalyzed Addition of 2-methylAzaarenesto Isatins via C-H Functionalization” Chin. J. Catal. 2012, 33, 1636. (IF = 2.63)

16. Wang Xiaowei, Li Xuting, Xiao Jian, Jiang Yi, Li Xingwei*, “Rh(III)-Catalyzed Oxidative Olefination of N-(Naphthalen-1-yl)amides” Synlett, 2012, 1649. (IF = 2.32)

15. Xiao Jian, Zhao Kai, LohTeck-Peng*,“Highly Enantioselective Intermolecular Alkylation of Aldehydes with Alcohols by Cooperative Catalysis of DiarylprolinolSilyl Ether with Brønsted Acid” Chem. Asian J. 2011, 6, 2890. (IF = 4.59)

14. Xiao Jian and Li Xingwei*, “Gold a-Oxo Carbenoids in Catalysis: Catalytic O-Atom Transfer to Alkynes” Angew. Chem. Int. Ed. 2011, 50, 7226. (IF = 13.26)

13. Xiao Jian, Lu Yun-Peng, Liu Yan-Ling, Wong Poh-Shen, LohTeck-Peng*, “A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly EnantioselectiveOrganocatalytic Michael Addition of Aldehydes to Vinyl Sulfones” Org. Lett. 2011, 13, 876.(IF = 6.73)

12. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, Liu Yan-Ling, LohTeck-Peng*, “Highly Efficient and Modularly Tuned Bicyclic Organocatalyst for the Enantioselective Michael Addition of Aldehydes to Nitroalkenes” Synthesis-Stuttgart, 2011, 1292. (IF = 2.69)

11. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, LohTeck-Peng*, “Chemzymes: A New Class of Structurally Rigid Tricyclic Amphibian Organocatalyst Inspired by Natural Product”

Org. Lett. 2010,12, 1220. (IF = 6.73) (Highlighted by Synfacts 2011, 5, 0561)

10. Xiao Jian, Wong Zhen-Zhou, Lu Yun-Peng, LohTeck-Peng*, “Hexahydropyrrolo[2,3-b]indoles: A New Class of Structurally Rigid Tricyclic Skeleton for Oxazaborolidine-Catalyzed Asymmetric Borane Reduction” Adv. Synth. Catal. 2010, 352, 1107. (IF = 6.45)

9. Xiao Jian and Loh Teck-Peng*,“The OrganocatalyticEnantioselective Michael Addition of Aldehydes to Vinyl Sulfones in Water” Synlett, 2010, 2029. (IF = 2.32)

8. Xiao Jian and Loh Teck-Peng*, “Design, Synthesis and Optical Resolution of New Bifunctional Ligand: 1,1′-Dimethyl-octahydro-8,8′-Biquinoline-7,7′-diol” Org. Lett. 2009, 11, 2876. (IF = 6.73)

7. Xiao Jian and Loh Teck-Peng*, “Unexpected Domino Ring Closure: Highly Stereoselective Construction of a Tetracyclic Indole Alkaloid Ring System” Tetrahedron Lett. 2008, 49, 7184. (IF = 2.35)

6. Xiao Jian and Loh Teck-Peng*, “Design and Synthesis of a Water-Tolerant Chiral Indium Complex: Application to One-Pot Three-Component Mannich-Type Reactions in Water” Synlett, 2007, 815. (IF = 2.32)

5. Xiao Jian, Lu Yong-Na, Wang Guo-Cang, Li Jin-Shan et al., “3-(3H-Inden-1-ylmethyl)-2,2'-bis(methoxymethoxy)1,1'-binaphthalenyl” Acta Crystallographica Section E, 2005, 61, O1501.

4. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, et al., “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Arylantimony Derivatives of Analogues of Demethylcantharimide”, J. Organomet. Chem., 2004, 689, 1631. (IF = 2.4)

3. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, Li Jin-Shan, “Synthesis, Characterization and in Vitro Cytotoxicity Screening of Some Triarylbismuth(V) di(N-salicylidene) Amino Carboxylates and the Crystal Structure of (2-HOC6H4CH=NCH2CO2)2Bi(C6H5)3” Appl. Organomet. Chem., 2005, 19, 113. (IF = 2.4)

2. Wang Guo-Cang, Lu Yong-Na, Xiao Jian, Li Jin-Shan, “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Organoantimony Arylhydroxamates” J. Organomet. Chem. 2005, 690, 151. (IF = 2.4)

1. Guo Qun-Sheng, Lu Yong-Na, Liu Bing, Xiao Jian, Li Jin-Shan, “A Facile Synthesis of 3 or 3,3′-Substituted Binaphthols and Their Applications in the Asymmetric Addition of Diethylzinc to Aldehydes” J. Organomet. Chem. 2006, 691, 1282. (IF = 2.4)

Patents

7. 肖建, 朱帅, 王亮,“一种无催化剂条件下构建三芳基和四芳基甲烷的方法”

申请号:201710504410.3

6. 肖建, 朱帅, 王亮,“一种合成吲哚取代或二茂铁取代氮杂芳烃的方法”

申请号:201710442072.5

5. 肖建,朱帅,“一种在无催化剂条件下构建四氢喹啉螺环骨架的方法”

申请号:201611038032.6

4. 肖建, 朱帅, 王亮,“一种氮杂芳烃苄位与缺电子芳环偶联的方法”

申请号:201611188837.9

3. 肖建,徐鲁斌,邵朱宙,“3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法”

申请号:201510679157.6

2. Loh Teck-Peng* and Xiao Jian “Process for Preparation of Octahydrobiquinoline Compounds”, PCT International Patent Application, 2010, 59pp. Patent Number: WO 2010132029

1. Loh Teck-Peng* and Xiao Jian “Preparation of Tricyclic Chiral Compounds and Their Use in Asymmetric Catalysis”, PCT International Patent Application, 2010, 141pp. Patent number: WO2010027334

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如果相逢总在山水外,莫如,在人生的渡口安然等待。看一段宿命,如何将你我的缘分,重新安排。