鲁莉华教授

 

鲁莉华,女,1979年11月生,博士,教授,硕士生导师

所属学科:应用化学、化学工艺

研究方向:金属配合物的设计与合成,铱(III)配合物在生物检测及荧光显像上的应用,基于铱(III)配合物的G-四链体探针的开发与应用,基于铱(III)配合物的药物筛选

教育及工作经历:

2018.09–至今 手机网投娱乐大全物理化学教研室,教授

2013.12–2018.09 手机网投娱乐大全物理化学教研室,副教授

2012.12–2015.12香港浸会大学化学系,Dik-Lung Ma课题组攻读博士

2015.09–2015.10 欧洲生物化学研究所(法国波尔多)交换学习, Jean-Louis Mergny研究组

2007.12–2013.12 手机网投娱乐大全网投娱乐大全物理化学教研室,讲师

2005.07-2007.10 手机网投娱乐大全理平台,助教

2002.09–2005.07 青岛科技大学化工平台化学工艺,硕士

1998.09–2002.07 青岛科技大学网投娱乐大全精细化工,本科

近五年科研成果总结介绍:

主要从事基于铱(Ⅲ)配合物的生物荧光传感设计与G-四链体探针的开发研究工作。目前主持国家自然科学基金青年项目、山东省自然科学基金面上项目、山东省高等学校科技计划项目和青岛市惠民计划项目各1项。在Chem. Sci., Anal. Chem., Biosens. Bioelectron., Acs Appl. Mater. Interfaces, Nanoscale等国际知名SCI期刊上发表研究论文30余篇。

近五年代表成果列表:(限10项)

(1) L. Lu, H. Su, Q. Liu, F. Li. Development of a Luminescent Dinuclear Ir (III) Complex for Ultrasensitive Determination of Pesticides. Anal. Chem. 2018, 90, 11716–11722. (Impact factor: 6.042, JCR一区)

(2) L. Lu, H. Su, F. Li*, Ultrasensitive Homogeneous Electrochemical Detection of Transcription Factor by Coupled Isothermal Cleavage Reaction and Cycling Amplification Based on Exonuclease III, Anal. Chem., 2017, 89, 8328–8334. (Impact factor: 6.320, JCR一区)

(3) L. Lu, D. S.-H. Chan, D.W.J. Kwong, H.-Z. He*, C.-H. Leung*, D.-L. Ma*. “Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe” Chem. Sci., 2014, 5, 4561–4567. (Impact factor: 9.144, JCR一区)

(4) H.-J. Zhong#, L. Lu#, C. C. L. Wong, C. Peng, S.-C. Yan, D.-L. Ma*, Z. Cai*, H.-M. D. Wang*, C.-H. Leung*. “An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent” Chem. Sci., 2015, 6, 5400–5407. (Co-first author, Impact factor: 9.144, JCR一区)

(5) L. Lu, M. Wang, L.-J. Liu, C.-H. Leung*, D.-L. Ma*. A label-free luminescent switch-on probe for ochratoxin A detection using a G-quadruplex-selective iridium(III) complex. ACS Appl. Mater. Interfaces, 2015, 7, 8313–8320. (Impact factor: 7.145, JCR一区)

(6) L. Lu*, C. Liu, H.-J. Zhong, G. Li, L.-J. Liu, C.-H. Leung*, D.-L. Ma*. Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment. Sensor Actuat. B-Chem., 2018, 257, 860–8657. (Impact factor: 5.401, JCR一区)

(7) L. Lu*, Z. Mao, T.-S. Kang, C.-H. Leung*, D.-L. Ma*. A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex. Biosens. Bioelectron., 2016, 85, 300–306. (Impact factor: 7.476, JCR一区)

(8) L. Lu*, W. Wang, C. Yang, T.-S. Kang, C.-H. Leung*, D.-L. Ma*. Iridium(III) complexes with 1,10-Phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection. J. Mater. Chem. B, 2016, 4, 6791–6796. (Impact factor: 4.872, JCR一区)

(9) L. Lu, M. Wang, L.-J. Liu, C.-Y. Wong, C.-H. Leung*, D.-L. Ma*. A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe. Chem. Commun., 2015, 51, 9953–9959. (Impact factor: 6.567, JCR一区)

(10) L. Lu, W. Wang, M. Wang, T.-S. Kang, J.-J. Lu, X.-P. Chen, Q.-B. Han, C.-H. Leung, D.-L. Ma*. A luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of lysozyme. J. Mater. Chem. B, 2016, 4, 2407–2411. (Impact factor: 4.872, JCR一区)

近五年主持科研项目:(限5项)

(1)国家自然科学基金青年项目,新型双核发光铱(Ⅲ)配合物的设计、合成及其在转录因子检测中的应用研究,21705089

(2)山东省自然科学基金面上项目,功能性双核发光铱(Ⅲ)配合物的设计、合成及其在肿瘤标志物检测中的应用研究,ZR2017MB064

(3)青岛市科技计划项目,动力学惰性铱(Ⅲ) 配合物的设计、合成及其在Aβ肽纤维化中的应用研究,18-6-1-83-nsh, 2018.09–2020.09

(4)山东省高等学校科技计划项目,基于新型双核发光铱(Ⅲ)配合物的肿瘤标志传感新方法研究,J17KA109

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