小坝子镇
二十里店

鲁莉华教授


鲁莉华1979.11

教授,理学博士,硕士研究生导师

专业:分析化学,化学工艺

联系电话:13954297004

电子邮件:lulihua2012@hotmail.com, lulihua2012@qau.edu.cn

工作经历

20189 手机网投娱乐大全物理化学教研室 教授

2013.122018.09 手机网投娱乐大全物理化学教研室 副教授

2015.092015.10 欧洲生物化学研究所(法国波尔多)交换学习, Jean-Louis Mergny研究组

2007.122013.12 手机网投娱乐大全网投娱乐大全,物理化学教研室,讲师

2005.07-2007.10 助教 手机网投娱乐大全理平台,助教

学习经历

201212201512月 博士 香港浸会大学化学系,Dik-Lung Ma课题组攻读博士

2002920057月  青岛科技大学化工平台 化学工艺,硕士

1998920027月  青岛科技大学网投娱乐大全,精细化工,本科

研究兴趣:基于G-四联体的生物传感器,金属配合物发光材料,基于金属配合物的药物筛选

代表性论文:

1L. Lu, H. Su, Q. Liu, F. Li. Development of a Luminescent Dinuclear Ir(III) Complex for Ultrasensitive Determination of Pesticides. Anal. Chem. 2018, 90, 11716–11722. (Impact factor: 6.042, JCR一区)

2L. Lu, H. Su, F. Li*, Ultrasensitive Homogeneous Electrochemical Detection of Transcription Factor by Coupled Isothermal Cleavage Reaction and Cycling Amplification Based on Exonuclease III, Anal. Chem., 2017, 89, 8328–8334. (Impact factor: 6.320, JCR一区)

3L. Lu, D. S.-H. Chan, D.W.J. Kwong, H.-Z. He*, C.-H. Leung*, D.-L. Ma*. “Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe” Chem. Sci., 2014, 5, 4561–4567. (Impact factor: 9.144, JCR一区)

4H.-J. Zhong#, L. Lu#, C. C. L. Wong, C. Peng, S.-C. Yan, D.-L. Ma*, Z. Cai*, H.-M. D. Wang*, C.-H. Leung*. “An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent” Chem. Sci., 2015, 6, 5400–5407. (Co-first author, Impact factor: 9.144, JCR一区)

5L. Lu, M. Wang, L.-J. Liu, C.-H. Leung*, D.-L. Ma*. A label-free luminescent switch-on probe for ochratoxin A detection using a G-quadruplex-selective iridium(III) complex. ACS Appl. Mater. Interfaces, 2015, 7, 8313–8320. (Impact factor: 7.145, JCR一区)

6L. Lu*, C. Liu, H.-J. Zhong, G. Li, L.-J. Liu, C.-H. Leung*, D.-L. Ma*. Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment. Sensor Actuat. B-Chem., 2018, 257, 8608657. (Impact factor: 5.401, JCR一区)

7L. Lu*, Z. Mao, T.-S. Kang, C.-H. Leung*, D.-L. Ma*. A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex. Biosens. Bioelectron., 2016, 85, 300–306. (Impact factor: 7.476, JCR一区)

8L. Lu*, W. Wang, C. Yang, T.-S. Kang, C.-H. Leung*, D.-L. Ma*. Iridium(III) complexes with 1,10-Phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection. J. Mater. Chem. B, 2016, 4, 67916796. (Impact factor: 4.872, JCR一区)

9L. Lu, M. Wang, L.-J. Liu, C.-Y. Wong, C.-H. Leung*, D.-L. Ma*. A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe. Chem. Commun., 2015, 51, 9953–9959. (Impact factor: 6.567, JCR一区) 

10L. Lu, W. Wang, M. Wang, T.-S. Kang, J.-J. Lu, X.-P. Chen, Q.-B. Han, C.-H. Leung, D.-L. Ma*. A luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of lysozyme. J. Mater. Chem. B, 2016, 4, 2407–2411. (Impact factor: 4.872, JCR一区)

11L. Lu, H.-Z. He, H.-J. Zhong, L.-J. Liu, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*. Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex. Sensor Actuat. B-Chem., 2014, 201, 177–182. (Impact factor: 4.758, JCR一区)

12L.-J. Liu#, L. Lu#, H.-J. Zhong, B. He, D.W.J. Kwong, D.-L. Ma*, C.-H. Leung*. An iridium(III) complex inhibits JMJD2 activities and acts as a potential epigenetic modulator. J. Med. Chem., 2015, 58, 6697–6673. (Co-first author, Impact factor: 5.589, JCR一区)

13Z.-Z. Dong#, L. Lu#, C. Yang, S. Li, M.-Y. Lee, C.-H. Leung*, D.-L. Ma*. A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe. Nanoscale, 2017, 9(14):4677–4682. (Co-first author, Impact factor: 7.760, JCR一区)

14C. Liu#, C. Yang#, L. Lu#, W. Wang, W. Tan, C.-H. Leung*, D.-L. Ma*. Luminescent iridium(III) complexes as the turn-on COX-2-specific imaging agents in cancer cells. Chem. Commun., 2017, 53(19):2822–2825. (Co-first author, Impact factor: 6.567, JCR一区)

15Z.-Z. Dong#, L. Lu#, W. Wang, G. Li, T.-S. Kang, Q. Han, C.-H. Leung*, D.-L. Ma*. Luminescent Detection of Nicking Endonuclease Nb.BsmI Activity by Using a G-quadruplex-selective Iridium(III) Complex in Aqueous Solution. Sensor Actuat. B-Chem. 2017, 246, 826–832. (Co-first author, Impact factor: 5.401, JCR一区)

在研课题:

1)国家自然科学基金青年项目,新型双核发光铱()配合物的设计、合成及其在转录因子检测中的应用研究,2170508925万,主持

2)山东省自然科学基金面上项目,功能性双核发光铱()配合物的设计、合成及其在肿瘤标志物检测中的应用研究,ZR2017MB06415万,主持

3)青岛市科技计划项目,动力学惰性铱() 配合物的设计、合成及其在肽纤维化中的应用研究,18-6-1-83-nsh10万,2018.09–2020.09,主持

4)山东省高等学校科技计划项目,基于新型双核发光铱()配合物的肿瘤标志传感新方法研究,J17KA1093.5万,主持

 

小坝子镇
二十里店
  • 利厚村
  • 莲埭
  • 苏庄
  • 中丁家沟
  • 中山路择仁里